Ccr3 Ccr4 Ccr5

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Sepsis, atherosclerosis Sepsis, atherosclerosis

Multiple sclerosis, rheumatoid arthritis, transplant AIDS, cancer

Multiple sclerosis, rheumatoid arthritis, transplant, asthma, nephritis Multiple sclerosis, rheumatoid arthritis, transplant, asthma, atherosclerosis Asthma Asthma

AIDS, multiple sclerosis, rheumatoid arthritis, transplant, asthma, nephritis, inflammatory bowel disease

(Simmons et al., 1996; Zhang et al., 1996), some strains can also use other chemokine receptors, such as CCR3 and CCR2b, as coreceptors for fusion and infection (Choe et al., 1996; Doranz et al., 1996). The viral fusion process may involve the initial binding of HIV-1 gp120 to its high-affinity receptor CD4, which results in conformational changes in gp120 and CD4 (Clements et al., 1991; Gershoni et al., 1993; Sattentau et al., 1993). The gp120-CD4 complex then interacts with a chemokine coreceptor such as CXCR4 or CCR5 to form a heterotrimeric complex of gp120-CD4-coreceptor (Lapham et al., 1996; Trkolaetal., 1996; Wuetal., 1996) (Fig. 12.1).

During the asymptomatic stage of disease, macrophage (M)-tropic strains of HIV-1 involved in sexual transmission primarily use CCR5 as an entry coreceptor

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When you hear the word arthritis, images of painful hands and joints comes into play. Few people fully understand arthritis and this guide is dedicated to anyone suffering with this chronic condition and wants relief now.

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