Human And Animal Bite Wound Infections

Human and animal bites may cause a wide spectrum of tissue damage, ranging from superficial breaks in the integument to cellulitis, septic arthritis, and osteomyelitis. In an emergency-room setting, the bite victim is often treated empirically with an oral antibiotic. The drug selected should possess activity against the polymicrobial flora most likely to cause such an infection. The culpable bacterial species include streptococci, staphylococci (usually S. aureus), Pasteurella multocida...

Antibacterial Agents And Inflammation

It is now recognized that antibacterial agents, whose main target is the microorganism, may also interfere with host cell functions 8 . The many studies which have been performed in vitro, ex vivo, and in vivo have raised the possibility that some antibacterial drugs may indeed alter the inflammatory response. It is well documented that ampicillin, penicillin G and various aminothiazolyl-cephalosporins possess oxidant-scavenging proper ties in vitro 9-11 , although in vivo j3-lactam treatment...

Diseases Caused By Spirochetes Erythema Chronicum Migrans

Erythema chronicum migrans ECM is the most important skin manifestation of Lyme disease. This tick-borne disease the most important one, accounting for over 90 of such diseases in the United States is caused by the spirochete Borrelia burgdorferi. Lyme disease is a systemic infection which particularly targets the skin, joints, heart, eyes, and the nervous system. In 1994, over 13,000 Lyme cases were reported to the Centers for Disease Control, although the diagnosis may be questioned in some...