The dietary supplement S-adenosyl-L-methionine (SAMe) has been reported to be effective for the management of a variety of problems, including depression, liver disease, and arthritis . It has been suggested that SAMe can reduce pain in osteoarthritis because it reduces inflammation, increases proteoglycan synthesis, or has an analgesic effect . It is unknown whether SAMe is an inhibitor of COX-2. Studies using human articular chondrocytes have shown SAMe-induced increases in proteoglycan synthesis . A double-blind crossover study compared SAMe (1200 mg) with celecoxib (Celebrex; 200 mg) for 16 weeks to reduce pain associated with osteoarthritis of the knee. Sixty-one adults diagnosed with osteoarthritis of the knee were enrolled, and 56 completed the study. The investigators reported that SAMe had a slower onset of action, but was as effective as celecoxib in the management of symptoms of knee osteoarthritis . They concluded that longer studies are needed to determine the long-term efficacy of SAMe and the optimal dose to be used.
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Did You Know That Herbs and Spices Have Been Used to Treat Rheumatoid Arthritis Successfully for Thousands of Years Do you suffer with rheumatoid arthritis Would you like to know which herbs and spices naturally reduce inflammation and pain 'Treating Rheumatoid Arthritis with Herbs, Spices and Roots' is a short report which shows you where to start.