Methylsulfonylmethane

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Methylsulfonylmethane (MSM) is another dietary supplement that is taken for the treatment of joint pain from arthritis. Its benefits for patients with osteoarthritis were investigated in a randomized, double-blind, placebo-controlled trial with 50 men and women (40-76 years old) with pain from osteoarthritis of the knee who were enrolled in an outpatient medical center [75]. The patients received MSM 3 g or placebo twice each day (6 g/d) for 12 weeks. The outcomes included the Western Ontario and McMaster University Osteoarthritis Index visual analog scale (WOMAC), patient and physician global assessments, and SF-36 (an overall health-related quality-of-life measurement).

  1. 2. Rates of primary response in the five groups in GAIT at 4 and 24 weeks. A primary response was defined as a 20% decrease in the summed score for the pain subscale of the WOMAC index. (From Clegg DO, Reda DJ, Harris CL, etal. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808; with permission.)
  2. 2. Rates of primary response in the five groups in GAIT at 4 and 24 weeks. A primary response was defined as a 20% decrease in the summed score for the pain subscale of the WOMAC index. (From Clegg DO, Reda DJ, Harris CL, etal. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808; with permission.)

The investigators reported that MSM resulted in significantly decreased WOMAC pain and physical function impairment (P < .05) compared with placebo, but no notable changes were found in WOMAC stiffness and aggregated total symptom scores [75]. MSM also produced improvement in performing activities of daily living compared with placebo on the SF-36 evaluation (P< .05). They concluded that MSM (3 g twice a day) improved symptoms of pain and physical function during a short intervention without major adverse events, although the long-term benefits and safety in managing osteoarthritis could not be confirmed by this pilot trial [75].

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Arthritis Joint Pain

Arthritis Joint Pain

Arthritis is a general term which is commonly associated with a number of painful conditions affecting the joints and bones. The term arthritis literally translates to joint inflammation.

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