Disordered sleep and fatigue are common features of diseases associated with chronic inflammation. For example, patients with autoimmune diseases (rheumatoid arthritis, multiple sclerosis, type 1 diabetes, Crohn's disease, and autoimmune thyroid disease) often report disturbed sleep and excessive fatigue (Bourguignon, Labyak, and Taibi 2003; Lashley 2003). Neuroimmune influences on sleep during autoimmune disease are the focus of other chapters of this book and will not be discussed here.
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