Pharmacodynamics in Disease States

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The pharmacodynamics of etanercept as it relates to the pathophysiology of a number of inflammatory disease states (i.e., rheumatoid arthritis, spondyloarthropathies [ankylosing spondylitis and psoriatic arthritis], and psoriasis) are described in the following sections.

TNF inactivated by etanercept binding

TNF inactivated by etanercept binding

Fig. 4.2. Mechanism of action of etanercept. TNF tumor necrosis factor. (Reprinted with permission from Amgen, Thousand Oaks, CA, USA)

Etanercept Mechanism Action

Fig. 4.2. Mechanism of action of etanercept. TNF tumor necrosis factor. (Reprinted with permission from Amgen, Thousand Oaks, CA, USA)

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Arthritis Joint Pain

Arthritis Joint Pain

Arthritis is a general term which is commonly associated with a number of painful conditions affecting the joints and bones. The term arthritis literally translates to joint inflammation.

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