Metabolism and Elimination

A single subcutaneous administration of 25 mg etanercept in patients with rheumatoid arthritis resulted in a mean half-life of 102 h (about 4 days) and a clearance rate of 160 ml/h, with no significant change in these pharma-cokinetic parameters observed with repeated dosing (Enbrel: US Full Prescribing Information 2005; Zhou 2005). Although not confirmed, it is thought that the elimination of etanercept occurs after it binds to TNF, and metabolism of the complex could occur through either peptide or amino acid degradation pathways. Amino acids could then be recycled or eliminated through the bile or urine (Culy and Keating 2002; Zhou 2005). The metabolites of etanercept are not bioactive.

Was this article helpful?

0 0
Arthritis Relief Now

Arthritis Relief Now

When you hear the word arthritis, images of painful hands and joints comes into play. Few people fully understand arthritis and this guide is dedicated to anyone suffering with this chronic condition and wants relief now.

Get My Free Ebook

Post a comment