Modern human genetics: an engine of hypothesis generation.
dramatically over the last several years. On the other hand, the costs and complexity of assembling large and well-characterized study populations are likely to remain high and become increasingly important for understanding how the newly discovered genes interact with each other, and with environmental factors, to cause disease. The required resources generally outstrip the capabilities of any single research group or institution. Thus, a collaborative effort among many investigators worldwide is the only rational way to proceed. Fortunately, this is now occurring for many autoimmune diseases, and it is therefore likely that a large fraction of the genes involved in human autoimmunity will be identified by the end of the decade.
PKG is supported by grants from the National Arthritis Foundation and the National Institutes of Health. We thank Dr. Franak Batliwalla for critical review and assistance with this manuscript.
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