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47 Auger I, Escola JM, Gorvel JP, Roudier J (1996) HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock proteins. Nat Med 2: 306-310

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54 Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez-Sueiro JL, Bal-ish E, Hammer RE (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 180: 2359-2364

55 Khare SD, Luthra HS, David CS (1995) Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondy-loarthropathies. J Exp Med 182: 1153-1158

56 Nickerson CL, Hanson J, David CS (1990) Expression of HLA-B27 in transgenic mice is dependent on the mouse H-2D genes. J Exp Med 172: 1255-1261

57 Khare SD, Hansen J, Luthra HS, David CS (1996) HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m. J Clin Invest 98: 2746-2755

58 Colbert RA, Rowland-Jones SL, McMichael AJ, Frelinger JA (1993) Allele-specific B pocket transplant in class I major histocompatibility complex protein changes requirement for anchor residue at P2 of peptide. Proc Natl Acad Sci USA 90: 6879-6883

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60 Allen RL, O'Callaghan CA, McMichael AJ, Bowness P (1999) Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure. J Immunol 162: 5045-5048

61 Kollnberger S, Bird LA, Roddis M, Hacquard-Bouder C, Kubagawa H, Bodmer HC, Breban M, McMichael AJ, Bowness P (2004) HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors. J Immunol 173: 1699-1710

62 Kollnberger S, Bird L, Sun MY, Retiere C, Braud VM, McMichael A, Bowness P (2002) Cell-surface expression and immune receptor recognition of HLA-B27 homodimers. Arthritis Rheum 46: 2972-2982

63 Popov I, Dela Cruz CS, Barber BH, Chiu B, Inman RD (2001) The effect of an anti-HLA-B27 immune response on CTL recognition of Chlamydia. J Immunol 167: 3375-3382

64 Popov I, Dela Cruz CS, Barber BH, Chiu B, Inman RD (2002) Breakdown of CTL tolerance to self HLA-B*2705 induced by exposure to Chlamydia trachomatis. J Immunol 169:4033-4038

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67 Boyle LH, Goodall JC, Opat SS, Gaston JS (2001) The recognition of HLA-B27 by human CD4(+) T lymphocytes. J Immunol 167: 2619-2624

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69 Guerau-de-Arellano M, Huber BT (2002) Development of autoimmunity in Lyme arthritis. Curr Opin Rheumatol 14: 388-393

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71 Steere AC, Dwyer E, Winchester R (1990) Association of chronic Lyme arthritis with HLA-DR4 and HLA-DR2 alleles. N Engl J Med 323: 219-223

72 Lengl-Janssen B, Strauss AF, Steere AC, Kamradt T (1994) The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis. J Exp Med 180:2069-2078

73 Steere AC, Falk B, Drouin EE, Baxter-Lowe LA, Hammer J, Nepom GT (2003) Binding of outer surface protein A and human lymphocyte function-associated antigen 1 pep-tides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis. Arthritis Rheum 48: 534-540

74 Gross DM, Forsthuber T, Tary-Lehmann M, Etling C, Ito K, Nagy ZA, Field JA, Steere AC, Huber BT (1998) Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 281: 703-706

75 Trollmo C, Meyer AL, Steere AC, Hafler DA, Huber BT (2001) Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells. J Immunol 166: 5286-5291

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77 Paisansinsup T, Deshmukh US, Chowdhary VR, Luthra HS, Fu SM, David CS (2002) HLA class II influences the immune response and antibody diversification to Ro60/Sjo-gren's syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules. J Immunol 168: 5876-5884

78 Paisansinsup T, Vallejo AN, Luthra H, David CS (2001) HLA-DR modulates autoantibody repertoire, but not mortality, in a humanized mouse model of systemic lupus erythematosus. J Immunol 167: 4083-4090

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