Cure Arthritis Naturally

Cure Arthritis Naturally

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24 Kuon W, Sieper J (2003) Identification of HLA-B27-restricted peptides in reactive arthritis and other spondyloarthropathies: computer algorithms and fluorescent activated cell sorting analysis as tools for hunting of HLA-B27-restricted chlamydial and autologous crossreactive peptides involved in reactive arthritis and ankylosing spondylitis. Rheum Dts Clin North Am 29: 595-611

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26 Ugrinovic S, Mertz A, Wu P, Braun J, Sieper J (1997) A single nonamer from the Yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis. J Immunol 159: 5715-5723

27 Kuon W, Holzhütter HG, Appel H (2001) Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associ-ated diseases. J Immunol 167: 4738-4746

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29 McGonagle D, Gibbon W, Emery P (1998) Classification of inflammatory arthritis by enthesitis. Lancet 352: 1137-1140

30 Poole AR (1998) The histopathology of ankylosing spondylitis: are there unifying hypotheses? Am J Med Sci 316: 228-233

31 Maksymowych WP (2000) Ankylosing spondylitis at the interface of bone and cartilage. J Rheumatol 27: 2295-2301

32 Braun J, Khan MA, Sieper J (2000) Enthesitis and ankylosis in spondyloarthropathy: what is the target of the immune response? Ann Rheum Dis 59: 985-994

33 Zhang Y (2003) Animal models of inflammatory spinal and sacroiliac joint diseases. Rheum Dis Clin North Am 29: 631-645

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38 Gao XM, Wordsworth P, McMichael A (1994) Collagen-specific cytotoxic T lymphocyte responses in patients with ankylosing spondylitis and reactive arthritis. Eur J Immunol 24: 1665-1670

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40 May E, Dulphy N, Frauendorf E, Duchmann R, Bowness P, Lopez de Castro JA, Tou-bert A, Marker-Hermann E (2002) Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen. Tissue Antigens 60: 299-308

41 Colbert RA (2004) The immunobiology of HLA-B27: variations on a theme. Curr Mol Med 4: 21-30

42 Allen RL, O'Callaghan CA, McMichael AJ, Bowness P (1999) Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure. J Im-munol162:5045-5048

43 Kollnberger S, Bird LA, Roddis M, Hacquard-Bouder C, Kubagawa H, Bodmer HC, Breban M, McMichael AJ, Bowness P (2004) HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors. J Immunol 173: 1699-1710

44 Boyle LH, Goodall JC, Opat SS, Gaston JS (2001) The recognition of HLA-B27 by human CD4(+) T lymphocytes. J Immunol 167: 2619-2624

45 Boyle LH, Hill Gaston JS (2003) Breaking the rules: the unconventional recognition of HLA-B27 by CD4+ T lymphocytes as an insight into the pathogenesis of the spondyloarthropathies. Rheumatology (Oxford) 42: 404-412

46 Yu D, Kuipers JG (2003) Role of bacteria and HLA-B27 in the pathogenesis of reactive arthritis. Rheum Dis Clin North Am 29: 21-36, v-vi

47 Penttinen MA, Heiskanen KM, Mohapatra R, DeLay ML, Colbert RA, Sistonen L, Granfors K (2004) Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: dependency on glutamic acid at position 45 in the B pocket of HLA-B27. Arthritis Rheum 50: 2255-2263

48 Sims AM, Wordsworth BP, Brown MA (2004) Genetic susceptibility to ankylosing spondylitis. Curr Mol Med 4: 13-20

49 Rudwaleit M, Höhler T (2001) Cytokine gene polymorphisms relevant for spondyloarthropathies. Curr Opin Rheumtol 13: 250-254

50 Laval SH, Timms A, Edwards S, Bradbury L, Brophy S, Milicic A, Rubin L, Siminovitch KA, Weeks DE, Calin A et al (2001) Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci. Am J Hum Genet 68: 918-926

51 Zhang G, Luo J, Bruckel J, Weisman MA, Schumacher HR, Khan MA, Inman RD, Mahowald M, Maksymowych WP, Martin TM et al (2004) Genetic studies in familial ankylosing spondylitis susceptibility. Arthritis Rheum 50: 2246-2254

52 Martin TM, Zhang G, Luo J, Jin L, Doyle TM, Rajska BM, Coffman JE, Smith JR, Becker MD, Mackensen F et al (2005) A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory disease. Arthritis Rheum 52: 269-274

53 Hoyle E, Laval SH, Calin A, Wordsworth BP, Brown MA (2000) The X-chromosome and susceptibility to ankylosing spondylitis. Arthritis Rheum 43:1353-1355

54 Yin Z, Braun J, Neure L, Wu P, Liu L, Eggens U, Sieper J (1997) Crucial role of inter-leukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis. Arthritis Rheum 40: 1788-1797

55 Braun J, Yin Z, Spiller I, Siegert S, Rudwaleit M, Liu L, Radbruch A, Sieper J (1999) Low secretion of tumor necrosis factor alpha, but no other Th1 or Th2 cytokines, by peripheral blood mononuclear cells correlates with chronicity in reactive arthritis. Arthritis Rheum 42: 2039-2044

56 Rudwaleit M, Siegert S, Yin Z, Eick J, Thiel A, Radbruch A, Sieper J, Braun J (2001) Low T cell production of TNFalpha and IFNgamma in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism. Ann Rheum Dis 60: 36-42

57 Tuokko J, Koskinen S, Westman P, Yli-Kerttula U, Toivanen A, Ilonen J (1998) Tumour necrosis factor microsatellites in reactive arthritis. Br J Rheumatol 37:1203-1206

58 Hohler T, Schaper T, Schneider PM, Meyer zum Buschenfelde KH, Marker-Hermann E (1998) Association of different tumor necrosis factor alpha promoter allele frequencies with ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum 41: 1489-1492

59 Kaluza W, Leirisalo-Repo M, Marker-Hermann E, Westman P, Reuss E, Hug R, Mas-trovic K, Stradmann-Bellinghausen B, Granfors K, Galle PR et al (2001) IL10.G microsatellites mark promoter haplotypes associated with protection against the development of reactive arthritis in Finnish patients. Arthritis Rheum 44: 1209-1214

60 Goedecke V, Crane AM, Jaakkola E, Kaluza W, Laiho K, Weeks DE, Wilson J, Kauppi M, Kaarela K, Tuomilehto J et al (2003) Interleukin 10 polymorphisms in ankylosing spondylitis. Genes Immun 4: 74-76

61 Howe HS, Cheung PL, Kong KO, Badsha H, Thong BY, Leong KP, Koh ET, Lian TY, Cheng YK et al (2005) Transforming growth factor beta-1 and gene polymorphisms in oriental ankylosing spondylitis. Rheumatology (Oxford) 44: 51-54

62 Jaakkola E, Crane AM, Laiho K, Herzberg I, Sims AM, Bradbury L, Calin A, Brophy S,

Kauppi M, Kaarela K et al (2004) The effect of transforming growth factor betal gene polymorphisms in ankylosing spondylitis. Rheumatology (Oxford) 43: 32-38

63 McGarry F, Neilly J, Anderson N, Sturrock R, Field M (2001) A polymorphism within the interleukin 1 receptor antagonist (IL-1Ra) gene is associated with ankylosing spondylitis. Rheumatology (Oxford) 40: 1359-1364

64 van der Paardt M, Crusius JB, Garcia-Gonzalez MA, Baudoin P, Kostense PJ, Alizadeh BZ, Dijkmans BA, Pena AS, van der Horst-Bruinsma IE (2002) Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in ankylosing spondylitis. Rheumatology (Oxford) 41: 1419-1423

65 Maksymowych WP, Reeve JP, Reveille JD, Akey JM, Buenviaje H, O'Brien L, Peloso PM, Thomson GT, Jin L, Russell AS (2003) High-throughput single-nucleotide polymorphism analysis of the IL1RN locus in patients with ankylosing spondylitis by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Arthritis Rheum 48: 2011-2018

66 Timms AE, Crane AM, Sims AM, Cordell HJ, Bradbury LA, Abbott A, Coyne MR, Beynon O, Herzberg I, Duff GW et al (2004) The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis. Am J Hum Genet 75: 587-595

67 Djouadi K, Nedelec B, Tamouza R, Genin E, Ramasawmy R, Charron D, Delpech M, Laoussadi S; EUROAS (2001) Interleukin 1 gene cluster polymorphisms in multiplex families with spondylarthropathies. Cytokine 13: 98-103

68 Jin L, Zhang G, Akey JM, Luo J, Lee J, Weisman MH, Bruckel J, Inman RD, Stone MA, Khan MA et al (2004) Lack of linkage of IL1RN genotypes with ankylosing spondylitis susceptibility. Arthritis Rheum 50: 3047-3048

69 Crane AM, Bradbury L, van Heel DA, McGovern DP, Brophy S, Rubin L, Siminovitch KA, Wordsworth BP, Calin A, Brown MA (2002) Role of NOD2 variants in spondylarthritis. Arthritis Rheum 46: 1629-1633

70 Peeters H, Vander Cruyssen B, Laukens D, Coucke P, Marichal D, Van Den Berghe M, Cuvelier C, Remaut E, Mielants H et al (2004) Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn's disease. Ann Rheum Dis 63: 1131-1134

71 van der Paardt M, Crusius JB, de Koning MH, Murillo LS, van de Stadt RJ, Dijkmans BA, Pena AS, van der Horst-Bruinsma IE (2003) CARD15 gene mutations are not associated with ankylosing spondylitis. Genes Immun 4: 77-78

72 Ferreiros-Vidal I, Amarelo J, Barros F, Carracedo A, Gomez-Reino JJ, Gonzalez A (2003) Lack of association of ankylosing spondylitis with the most common NOD2 susceptibility alleles to Crohn's disease. J Rheumatol 30: 102-104

73 Brown MA, Edwards S, Hoyle E, Campbell S, Laval S, Daly AK, Pile KD, Calin A, Ebringer A, Weeks DE et al (2000) Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis. Hum Mol Genet 9: 1563-1566

74 Yen JH, Tsai WC, Chen CJ, Lin CH, Ou TT, Hu CJ, Liu HW (2003) Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. Immunol Lett 88: 113-116

75 van der Paardt M, Crusius JB, de Koning MH, Morre SA, van de Stadt RJ, Dijkmans BA, Pena AS, van der Horst-Bruinsma IE (2005) No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis. Ann Rheum Dis 64: 235-238

76 Jin L, Weisman M, Zhang G, Ward M, Luo J, Bruckel J, Inman R, Khan MA, Schumacher HR, Maksymowych WP et al (2005) Lack of association of matrix metallopro-teinase 3 (MMP3) genotypes with ankylosing spondylitis susceptibility and severity. Rheumatology (Oxford) 44: 55-60

77 Timms AE, Zhang Y, Bradbury L, Wordsworth BP, Brown MA (2003) Investigation of the role of ANKH in ankylosing spondylitis. Arthritis Rheum 48: 2898-2902

78 Tsui HW, Inman RD, Paterson AD, Reveille JD, Tsui FW (2005) ANKH variants associate with ankylosing spondylitis: gender differences. Arthritis Res Ther 7: R513-R525

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Arthritis Joint Pain

Arthritis Joint Pain

Arthritis is a general term which is commonly associated with a number of painful conditions affecting the joints and bones. The term arthritis literally translates to joint inflammation.

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