Index

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acute myeloid leukaemia 81 aggrecan 139

analysis, discovery driven 121 analysis, hypothesis driven 121 analysis, statistical 121

animal models, for arthritis regulating genes 165

ankylosing spondylitis (AS) 96, 136, 139

anti-CCP antibody 51

anti-citrullinated peptide antibody 50

anti-keratin antibody 50

antiperinuclear factor 50

anti-Sa antibody 50

array hybridisation 120

arthritogenic peptide hypothesis 93

association studies, rheumatoid arthritis 17

autoantibodies 50

autoantigens 93

autoimmune diseases 131

autoimmune arthritis 147

B10.M 133

B27 transgenic rat model 92 bacterial infection 91 BALB/c mouse 135 biobanked patient sample 107 bioinformatics, modelling 125 biomarker 30, 31, 108 biomarker pattern 108 Borrelia burgdorferi 139, 140

C3H mouse 135

cartilage 94

CBFß subunit 80

CD4 132-134

cellular states 108

Chlamydia 138

Chlamydia trachomatis 91, 92

chondrocyte 134

chondrocyte development 81

chromosomal translocation 81

CIA 134, 135

citrullination 48

citrulline 50

class I 138

class II 135, 138

congenic strain 166

Crohn's disease 52

cytochrome P450 complex 98

cytokine pattern 96, 134

cytotoxic CD8+ T-cell 93

DBA/1 133

diagnostic and prognostic marker 30 disease heterogeneity 30, 33 DNA-ligation-based techniques for molecular analyses 111 DNA microarray technology 33 DNA sequencing 108 DQ8 136 DR1 133, 135

DR4 133, 135, 140

ectopic lymph node 36, 38 enthesitis 136

familial aggregation of RA cases 79 fibroblast-like synoviocyte (FLS) 36 functional polymorphism PD1.3 80

gastric cancer 81 gene expression analysis 163 gene expression profile/profiling 33, 35, 36, 108, 119

gene-based approach, SNPs 45 genetic heterogeneity 167 genetic trait 120 genome scan 13

Genome Screen Meta-Analysis (GSMA) 16 genotyping 108 P-glucan 154

glycosylated forms of CII 134

haplotypes, SNP-based 43 Hapmap project 43 heat shock protein 60 93 hematopoietic development 81 heterogeneity in/of RA 38 high inflammation tissue 36 high-throughput technology 31 HLA 131-133 HLA-B27 91, 95, 136-139 HLA-B27 homodimer (B272) 95, 138 HLA-B27 misfolding hypothesis 95 HLA-B27 subtype 91 HLA-DQ8 135 HLA-DR 135 HLA-DR1 (DRB1*0101) HLA-DR2 140 HLA-DR4 140 HLA-DR4 (DRB1*0401 HLA-DR4 (DRB1*0402 HLA-DR4 (DRB1*0404)

HLA-DR4 (DRB1*0405) 132 HLA-DR4 (DRB1*0408) 132 HLA-DR6 (DRB1*1402) 132 HLA-DR10 (DRB1*1001) 132, 133 HLA-DRB1*0401 140 human cartilage glycoprotein 39 (HCgp39) 133, 134

human leukocyte antigens (HLA) Class I 131 human leukocyte antigens (HLA) Class II 131-133

human leukocyte function-associated antigen 1

(LFA-1) 140 humanized mouse 132-134, 140 humanized murine model 139

IL-10 gene polymorphism 97 immunoreceptor PD-1 79 in situ analyses 111 incomplete penetrance, RA 167 inflammatory bowel disease 91 interleukin-1 gene cluster 97

laser microdissection 121 LD block 45 leukaemia 81 LFA-1 140

linkage analysis 13, 166

linkage association 164

linkage disequilibrium 17

linkage disequilibrium (LD) mapping 43, 45

low inflammation tissue 37

lupus erythematosus, systemic 120

Lyme arthritis 140

Lyme disease 139, 140

major histocompatibility complex (MHC) 131, 137

map-based approach 45 marker gene 125

131, 133

132-134 134, 136 132

marker, molecular 119 MHC Class I 137 P2-microglobulin (P2m) 137-139 modelling, molecular network 119 molecular mimicry 140 molecular variation among patients 36 monocyte 122 monozygotic twins 90 multifactorial nature of the disease 30 multiparameter screen 120 myeloid leukaemia 81 myofibroblast-like cell 37, 38

NAT9 52 NAT9 83

neutrophilic cytosolic factor 1 (Ncf1) 167 NOD 2 (CARD15) genotype 97

organic cation transporter gene SLC22A4 52, 83 outer surface protein A (OspA) 140

parallel genotyping 108, 111 PDCD1 52

peptidylarginine deiminase type 4 (PADI4) 45, 48

peripheral arthritis 136

personalised medicine/therapy 29, 39

pharmacogenetics 168

polygenic inheritance 167

population stratification 20

positional cloning 164, 166

positive and negative selection 151

prevalence of RA 11

protein array 31

protein expression profiling 38

protein measurement 110

protein modification 122

proteoglycan 133, 135

proteoglycan induced arthritis (PGIA) 135

proteomics 38

psoriasis 52, 83

PTPN22 156

reactive arthritis (ReA) 89, 96, 137 regulatory T (TR) cell 151 reverse genetics 166 runt-domain-encoding genes 80 RUNX1 52, 80 RUNX2 80 RUNX3 80

RUNX3 in inflammation 82

sacroiliitis 136

Salmonella enteritides 95

self-reactive CD4+ T-cell 147

shared epitope 136

sibling risk ratio 12

signal transduction in T-cell 151

signalling, extracellular 123

signalling, intracellular 123

SLC22A4 52, 83

SLC22A5 52

SLC9A3R1 52

SLC9A3R1 83

SNPs 43

spondyloarthritides (Spa) 89 spondyloarthropathy 136, 138 stratification, diagnostic, therapeutic 120 synoviocyte 36 synovitis 147

systemic lupus erythematosus 120

TGF-P 82, 97 Th1 139

Th2 cytokines 139

TNF-a gene 96

TNF-a microsatellite 96

total genetic risk in AS 96

transcriptome, analysis 119

transcriptome, biological importance 122

transcriptome, biological system 121

transcriptome, cell infiltration 122

transcriptome, cellular composition 122

transcriptome, functional signature 120

transcriptome, mRNA abundance 122 transforming growth factor (TGF) beta 82, 97 type II collagen (CII) 133-136 tyrosine phosphatase 61, 65

whole genome scan 13

Yersinia enterocolitica 92 Yersinnia pestis 71

ZAP-70 147 zymosan 154

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