HLAB27 may present arthritogenic peptides

In addition to serving as a direct mediator of disease via inefficient folding and inappropriate dimerization, it has also been suggested that HLA-B27 may precipitate spondyloarthropathy by presenting arthritogenic peptides. The fact that the environment in which mice transgenic for HLA-B27 are raised affects arthritis incidence suggests that presentation of bacterial antigens may play a role in HLA-B27-medi-ated disease. Most of the rodent-based experiments involving bacterial peptides and HLA-B27 have been performed using an HLA-B27 transgenic rat model that is dependent upon P2m expression. Using LEW rats transgenic for HLA-B27 and human P2m, Popov et al. found that when the rats were immunized against HLA-B27 and restimulated in vitro with Chlamydia infected B27+ cells, CTL developed to both B27+ targets as well as Chlamydia infected syngeneic targets [63, 64]. These data indicated that CTLs were generated that recognize both HLA-B27 and

Chlamydia, implicating "a dynamic relationship between recognition of B27 peptides and Chlamydia peptides", although evidence of cross recognition of peptides is still lacking [63].

HLA-B27 animal models have also been useful for the study of other candidate antigens for AS, including autologous proteins such as the cartilage protein aggre-can. Using HLA-B27 transgenic mice immunized with human aggrecan peptides, Kuon et al. found that CD8+ T-cells from these mice were stimulated only by the human peptides and not by their murine counterparts [65]. The relevance of this murine HLA-B27 transgenic model is supported by a clinical study performed by Atagunduz et al. who found that CD8+ T-cells from synovial fluid and blood mononuclear cells from HLA-B27+ AS patients could be stimulated by cartilage antigens [66].

Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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