Contents

Cure Arthritis Naturally

Beat Arthritis Naturally

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List of contributors vii

A. Introduction

Rikard Holmdahl

Genetics of joint inflammation - problems and possibilities 3

B. Genetic studies on rheumatic diseases

Jane Worthington, Anne Barton and Sally L. John

The epidemiology of rheumatoid arthritis and the use of linkage and association studies to identify disease genes 9

Cornelis L. Verweij and Tineke C.T.M. van der Pouw Kraan

Heterogeneity in rheumatoid arthritis based on expression analysis:

towards personalised medicine 29

Ryo Yamada and Kazuhiko Yamamoto

Gene-based large scale LD-mapping of rheumatoid arthritis-

associated genes 43

C. Shared heredity of rheumatic diseases

Peter K. Gregersen and Robert M. Plenge

Emerging relationships: rheumatoid arthritis and the PTPN22 associated autoimmune disorders 61

Marta E. Alarcon-Riquelme and Sergey V. Kozyrev

Shared genes in rheumatic diseases, the role of PD1 and the RUNX genes in disease susceptibility 79

Joachim Sieper and Martin Rudwaleit

The role of B27 and other genes associated with ankylosing spondylitis 89

D. Tools for analysing complexity

Ulf D. Landegren

Emerging tools for dissecting complex disease 107

Thomas Häupl, Andreas Grützkau, Joachim Grün, Andreas Radbruch and Gerd-R. Burmester

Expression analysis of rheumatic diseases, prospects and problems 119

Kary A. Latham, Timothy D. Kayes, Zhaohui Qian and Edward F. Rosloniec The use of humanized MHC mouse strains for studies of rheumatic diseases 131

Shimon Sakaguchi, Takeshi Takahashi, Hiroshi Hata, Hiroyuki Yoshitomi,

Satoshi Tanaka, Keiji Hirota, Takashi Nomura and Noriko Sakaguchi

SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T-cells 147

Peter J. Olofsson

A genetic approach to select and validate new targets for treatment of rheumatic diseases 161

Index 175

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Arthritis Joint Pain

Arthritis Joint Pain

Arthritis is a general term which is commonly associated with a number of painful conditions affecting the joints and bones. The term arthritis literally translates to joint inflammation.

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