Humanized mice as models for rheumatoid arthritis

While rheumatoid arthritis (RA) remains an autoimmune disease of unknown etiology, susceptibility to RA is clearly associated with the expression of several human leukocyte antigens (HLA), including HLA-DR1 (DRB1*0101), HLA-DR4 Table 1 - Humanized mouse models of rheumatic diseases Table 1 - Humanized mouse models of rheumatic diseases DR6 (DRB1*1402) 1-3 . The relative risk and severity of RA varies among these susceptible HLA alleles, with Caucasian individuals expressing the *0401 allele...