Differences In Transdermal Technology And Pharmacology Of Fentanyl And Buprenorphine

Butrans Patch Excipients

Because of the difference in construction between both transdermal systems, the reservoir and the matrix composition, one has to be aware of possible side effects of the former. When using the old reservoir system, an additional rate limiting control membrane guarantees a steady stream of the active compound fentanyl into the skin. Contrary, in the matrix composition the active compound is incorporated in a polymer layer Fig. IV-14 . Because of this difference the reservoir system should never...