Abstract

Obesity is one of the most common physical health care problems among persons with severe and persistent mental illness. Obesity is a complex multifactorial chronic disease that develops from the interaction between genotype and the environment. Among individuals with serious mental illnesses, an unhealthy lifestyle, as well as the effects of psychotropic medications, such as second-generation antipsychotics, can contribute to the development of this problem. Excess body weight increases the...

Effect of Antipsychotic Drugs on the Immune Response in Schizophrenic Patients

Both in vitro and in vivo studies have suggested that effective antipsychotic treatment corrects the imbalance between the cellular and humoral arms of the adaptive immune system 4, 27 . Both haloperidol and clozapine, for example, have been shown to increase the release of IL-2 and IFN from whole blood cultures in vitro, whereas the antidepressant amitriptyline was ineffective 28 . In vivo, IL-18, a cytokine that also originates from activated Th-1 cells, is also increased following effective...

Lifestyle Therapies and Other Nonpharmacological Interventions

Maintaining a normal weight, even without the additional challenges frequently associated with mental illness, is difficult for most individuals. There is a commonly held belief that persons with schizophrenia cannot make lifestyle changes that improve ones' health such as choosing to eat healthier, becoming more physically active, and achieving significant weight loss. However, research in the form of controlled clinical trials as listed in table 3 suggests that people with schizophrenia are...