P2x7

Vasoconstriction Diagram

(or ionic current) fades away very rapidly (within a few hundred milliseconds) by a process termed desensitiza-tion. Desensitization does not occur, or is much slower at the other P2X receptors. The P2X7 receptor is a most unusual ion channel in that it not only opens to allow bidirectional flux of cations in a manner similar to that described above for typical ionotropic receptors. However, it also dilates over several seconds to minutes to a size that allows the passage of molecules of either...