Relapsing Polychondritis

Relapsing Polychondritis Ears

Etiology Unknown, antibodies against type II collagen are common HLA-DR4 association Associations Myelodysplastic syndromes, systemic vasculitis, connective tissue autoimmune diseases Clinical Erythematous, painful ear s , nose, arthropathy, respiratory, Histology Frequently nonspecific, degenerative changes of cartilage with fibrosis and lymphocytic infiltrate at chondrofibrous junction IF Immunoglobulin and C3 at chondrofibrous junction Evaluation CBC, creatinine, urinalysis, ESR, RF, PFTs,...

Pancreatic Panniculitis

Panniculitis

Synonyms Pancreatic fat necrosis, nodular fat necrosis of pancreatic disease Etiology In part, due to cutaneous enzymatic fat necrosis from circulating pancreatic enzymes Associations Acute and chronic pancreatitis, acinar cell carcinoma Clinical Erythematous subcutaneous nodules favoring lower extremities, may drain spontaneously arthritis, serositis, abdominal pain, nausea, vomiting, lytic bone lesions Histology Subcutaneous fat necrosis with loss of adipocyte nuclei, ghost cells, stippled...