The mere presence of urate crystals in the joint cannot be correlated with the appearance of acute gouty arthritic symptoms. Individuals who have never had any gouty arthritic problems have nonetheless been found to have uric acid deposited on their articular cartilage. Acute attacks are generally the result of granulocytic phagocytosis of the urate crystals. This engulfing of the crystals is accompanied by cellular release of chemotac-tic lipids, lysosomal enzymes, and acidic substances into the synovial tissues. The lipids appear to trigger further phagocytosis, whereas the acidic compounds decrease local pH to the point that increased urate crystal formation is favored.
In addition to the phagocytic activity of the leukocytes, small peptide substances, such as the kinins, which are thought to be partially responsible for the local inflammatory response in gouty arthritis, accumulate in the joint space. The inflammation is associated with local vasodilation, increased vascular permeability, and pain.
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Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.