Nonsteroidal Antiinflammatory Drugs

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The nonsteroidal anti-inflammatory drugs (NSAIDs) have a variety of clinical uses as antipyretics, analgesics, and anti-inflammatory agents. They reduce body temperature in febrile states and thus are effective antipyretics. They are also useful as analgesics, relieving mild to moderate pain (see Chapter 26) such as myalgia, dental pain, dysmenorrhea, and headache. Unlike the opioid analgesics, they do not cause neurological depression or dependence. As anti-inflammatory agents, NSAIDs are used to treat conditions such as muscle strain, tendinitis, and bursitis. They are also used to treat the chronic pain and inflammation of rheumatoid arthritis (adult onset and juvenile), osteoarthritis, and arthritic variants such as gouty arthritis and ankylosing spondylitis. While NSAIDs used to be the sole agent of choice for mild to moderate rheumatoid disease, they are now frequently used in conjunction with the disease-modifying antirheumatic drugs (DMARDs) early in the treatment of these disorders. This is because the NSAIDs reduce pain and inflammation associated with rheumatoid diseases but do not delay or reverse the disease's progress.

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Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

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