Info

Yes

IM, intramuscular;IV, intravenous.

IM, intramuscular;IV, intravenous.

For parenteral therapy, nafcillin and oxacillin offer comparable efficacy and antimicrobial spectra of activity. Although both drugs undergo hepatic metabolism, only nafcillin requires dose adjustment in patients with combined hepatic and renal insufficiency. Other pharmacokinetic data for nafcillin and oxacillin appear in Table 45.1. Indications for nafcillin or oxacillin include severe staphylococcal infections like cellulitis, empyema, endocarditis, osteomyelitis, pneumonia, septic arthritis, and toxic shock syndrome.

For oral therapy, cloxacillin and dicloxacillin are comparable alternatives. Both undergo hepatic metabolism, and neither drug requires dose adjustment in patients with hepatic insufficiency. Additional pharmaco-kinetic data are in Table 45.1. Indications for cloxacillin or dicloxacillin include clinically mild staphylococcal infections like impetigo.

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Treating Rheumatoid Arthritis With Herbs Spices Roots

Treating Rheumatoid Arthritis With Herbs Spices Roots

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