Immunosuppressive Drugs

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The immunosuppressive drugs are used in rheumatoid arthritis and certain other autoimmune conditions that are refractory to less toxic treatments. Their pharmacology and additional clinical uses are described in Chapter 57. Azathioprine (Imuran) is a prodrug that is metabolized to a purine antimetabolite. Its disease-modifying activity results from the inhibition of lymphocyte proliferation and secretion of certain cytokines. This drug is used in the treatment of rheumatoid arthritis, lupus nephritis, and psoriatic arthritis. Cyclosporine (Sandimmune, Neoral) is used in refractory rheumatoid arthritis, psoriasis, and inflammatory bowel disease. It acts by blocking the transcriptional activation of many genes involved in the first phase of T cell activation. Cyclophosphamide (Cytoxan) is an alkylating agent that was used in severe rheumatoid in the past but is seldom used today because of its severe bladder toxic-ity, bone marrow toxicity, and carcinogenicity.

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Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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