Other Salts Of Salicylic Acid

Sodium thiosalicylate (Rexolate) is the sulfur or thio analog of sodium salicylate. It is more soluble and better absorbed, thus allowing lower dosages. It is recommended for gout, rheumatic fever, and muscular pains, but it is available only for injection. Magnesium salicylate (Mobidin, Magan) is a sodium-free salicylate preparation for use when sodium intake is restricted. It is claimed to produce less GI irritation. Choline salicylate (Arthropan) is extremely soluble in water and is...

O Nonsteroidal Antiinflammatory Drugs

NSAIDs including aspirin and acetaminophen, two of the oldest pain medications, are among the most widely prescribed drugs worldwide for the treatment of rheumatic arthritis and other degenerative inflammatory joint dis-eases.126,127 Although NSAIDs are very effective in relieving mild to moderate pains and inflammation, their use is also often associated with many undesirable side effects, including GI irritation and bleeding, platelet dysfunction, kidney damage, and bronchospasm.126-129 With...

Colchicine

Colchicine is an alkaloid isolated from the dried corns and seeds of Colchicum autumnale L, commonly known as autumn crocus or meadow saffron, (see Fig. 24.26 for structure). It is specifically indicated for acute treatment of gouty arthritis because of its ability to block the production and release of the CCF that mediates the inflammatory response because of urate crystals, a mechanism different from colchicine's antimitotic action, which is being investigated for its anticancer...

Ho

Although the antisecretory effects of misoprostol are thought to be related to its agonistic actions at parietal cell prostaglandin receptors, its cytoprotective actions are proposed to be related to increases in GI mucus and bicarbonate secretion, increases in mucosal blood flow, and or prevention of back diffusion of acid into the gastric mucosa.80 Misoprostol is rapidly absorbed following oral administration and undergoes rapid deesterification to the pharmacologically...

RDNA Technology

RDNA technology frequently has been referred to as genetic engineering or gene cloning. A comprehensive discussion of the process and application of rDNA technology is available in several good reviews.72,75-77 The concept of genetic engineering is based on the fact that the genetic material (DNA) in all living organisms is made of the same four building blocks, that is, four different deoxymononu-cleotides. Therefore, genetic material from one organism or cell may be combined with the genetic...

O Drugs Used In The Management Of Gout And Hyperuricemia

In contrast to RA discussed earlier, gout is somewhat unique, in that its cause is well known, therefore gouty inflammation can be effectively controlled and treated with medications.240,241 Gout is one of the most common causes of acute inflammatory arthritis in men older than 40 years old, characterized by the deposition of monosodium urate crystals in the joints and cartilage.242 Phagocytosis of urate crystals by human neutrophils (and macrophage) induces the synthesis and release of a...

O Stimulation Of Antimalarial Research By

From 1941 to 1946 (World War II), more than 15,000 substances were synthesized and screened as possible antimalar-ial agents by the United States, Australia, and Great Britain. Activity increased again during the Vietnam War, especially because of the increasing problem of resistance to commonly used antimalarials. During the decade 1968 to 1978, more than 250,000 compounds were investigated as part of a U.S. Army search program.21 Department of Defense funding of this research has continued....

Carolyn J Friel And Matthias C Lu

The terms analgesics and analgetic drugs are often used interchangeably to describe a diverse group of pain medications such as opioids, nonsteroidal anti-inflammatory drugs NSAIDs , and triptans, each with very different mechanisms of action for relieving pains of a wide array of causes. Analgesics can be broadly categorized, according to their therapeutic use, into several drug classes a the opioids or narcotic analgesics , which play a major role in the relief of acute pain and in the...