Prolotherapy is a long-described intervention whereby pain of musculoskele-tal origin is treated by injection of a dextrose/lidocaine solution into connective tissue sites that are thought to be related to the genesis and perpetuation of pain. Prolotherapy has been used in the treatment of discogenic low back pain; chronic cervical, thoracic, or lumbar pain; osteoarthritis; and failed back surgery (postspinal surgery) pain (Linetsky et al. 2006). Contraindications include treatment of patients with pain related to neoplastic processes and patients requiring large quantities of narcotic analgesics before and after treatment. Prolotherapy may be employed in conjunction with other procedures (e.g., peripheral nerve blocks).
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