Introduction

Cure Arthritis Naturally

Cure Arthritis Naturally

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Reactive oxygen species (ROS) are produced in the cells by various environmental stimuli such as infection of microbes (viruses, bacteria, etc.), ionizing and UV irradiation, and pollutants (i.e., oxidants), which are collectively called "oxidative stress.'' These environmental challenges elicit inflammatory and immune responses (1). Interestingly, these factors are also regarded as risk factors and disease-accelerating factors for autoimmune diseases including rheumatoid arthritis (RA) (Fig. 1). In addition, inflammatory responses in mammals are often associated with ROS production from neutrophils and macrophages. Therefore, this natural

Figure 1 Involvement of ROS in autoimmunity and RA. (A) Reactive oxygen species production is either directly or indirectly induced by environmental factors during the inflammatory process. (B) Induction of autoimmune response by ROS through the stress-responsive signaling and oxidative modification of autoantigens.

Figure 1 Involvement of ROS in autoimmunity and RA. (A) Reactive oxygen species production is either directly or indirectly induced by environmental factors during the inflammatory process. (B) Induction of autoimmune response by ROS through the stress-responsive signaling and oxidative modification of autoantigens.

defense system for the organism contains a potentially dangerous option conforming a positive feed-back loop which is considered responsible for further augmentation and expansion of the response if the feed-back regulatory system, antioxidant system, and negative-cytokine network do not work efficiently.

Rheumatoid arthritis is a common human autoimmune disease with a prevalence of about 1% (2). While there has been progress in defining its etiology and pathogenesis, these are still incompletely understood (3-5). Rheumatoid arthritis is characterized by a chronic inflammation of the synovial joints associated with proliferation of synovial cells and infiltration of activated immuno-inflammatory cells, including memory T cells, macrophages, and plasma cells (4-6), leading to progressive destruction of cartilage and bone. This process is considered to be mediated by a number of cytokines such as TNFa, IL1, IL-6, IL-8, IL-12, IL-16, IL-18, and IFNy (reviewed in Refs. 2-5).

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Natural Arthritis Pain Remedies

Natural Arthritis Pain Remedies

It's time for a change. Finally A Way to Get Pain Relief for Your Arthritis Without Possibly Risking Your Health in the Process. You may not be aware of this, but taking prescription drugs to get relief for your Arthritis Pain is not the only solution. There are alternative pain relief treatments available.

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