The Role of Cytokines in Osteoarthritis

Mechanical Osteoarthritis

Inflammation and accompanying dysregulated cytokine catabolic activities play key roles in OA pathogenesis in addition to the effects of age and excessive mechanical loading (for review, see 70,74,121 (Fig. 3.2). Osteoarthritis is not considered a classical inflammatory arthropathy, because of the absence of neutrophils in the synovial fluid and the lack of systemic manifestations of inflammation. Nevertheless, synovial inflammation is common in both early and late stages of OA 19 . The...