Decoy Oligodeoxynucleotides to Treat Inflammatory Diseases

Markus Hecker, Swen Wagner, Stefan W. Henning and Andreas H. Wagner 7.2 Decoy Oligonucleotide Synthesis 164 7.3 Decoy Oligonucleotide Administration 165 7.4 Mechanism of Action 168 7.4.1 Target Identification 169 7.4.2 Target Specificity 170 7.4.3 Sequence Optimization for Cellular Uptake 172 7.5 Therapeutic Applications 174 7.5.2 Atherosclerosis and Related Vascular Remodelling Processes 176 7.5.3 Inflammatory Skin Disease 178 7.5.4 Rheumatoid Arthritis 181 7.5.5 Acute and Chronic Transplant...

Rheumatoid Arthritis

Apart from arthrosis, rheumatoid arthritis is the most prevalent (approximately 1 in Caucasians) and severe chronic inflammatory disease of the joints, with a particularly high socioeconomic impact. It is thought to be an immune-mediated disease that promotes inflammation and progressive destruction of the joints. Besides the pro-inflammatory cytokines TNFa, IL-1 p and IL-6, which mainly derive from macrophages, a dominant type 1 Th cell response is associated with the disease that is...

References

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Inflammatory Skin Disease

T-Cell mediated skin diseases, mainly comprising psoriasis (prevalence > 2 ), allergic contact dermatitis (ACD, prevalence about 9 ) and atopic dermatitis (prevalence > 3 in developed countries and especially among Caucasians), are the most prevalent and severe chronic inflammatory skin diseases. While psoriasis is thought to be based primarily on an exaggerated Th1 or maybe Th17-type immune response, atopic dermatitis more likely represents an overt Th2-type immune response. ACD lies...