Cortisone and hydrocortisone help to regulate the body's glucose. Since the late 1940s, corticosteroids have been used medically to alter and suppress immune function. With a phenomenal range of applications, corticosteroids were quickly adopted as "miracle cures'' for the full range of autoimmune diseases, including the difficult-to-manage rheumatoid arthritis. However, it did not take long for clinicians and researchers to discover that there was a severe cost for chronic corticosteroid use. Countless patients developed physical conditions that, prior to such widespread use of these agents, were rarely seen by practitioners of Western medicine such as osteoporosis, poor wound healing, abdominal obesity, hypertension, hyperglycemia, and fluid retention. Poorly monitored corticosteroid administration can result in a condition similar to Cushing's syndrome, an endogenous hypercortisolemia disease. A temporary treatment with very low doses of cortisone may be beneficial, however, in patients with severe adrenal exhaustion.
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