References

Albertsson PA, Basse PH, Hokland M, Goldfarb RH, Nagelkerke JF, Nannmark U, Kuppen PJ. (2003) NK cells and the tumour microenvironment implications for NK-cell function and anti-tumour activity. Trends Immunol 24 603-609 Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D. (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science 298 1395-1401 Basse PH, Hokland P, Gundersen HJ, Hokland...

KIR Effects in Autoimmune and Inflammatory Diseases

Historically, the most robust disease associations with the highly polymorphic HLA class I class II loci have been autoimmune in nature, and only very few infectious diseases have shown strong, consistent HLA associations Cooke and Hill 2001 Gao et al. 2001 . It would not be surprising if the strongest effects of KIR variation were also observed in autoimmune diseases. Some previously determined HLA associations with autoimmune diseases might actually be explained by synergistic interactions...

Role of NKG2D and CD94NKG2 Receptors in Organ Specific Autoimmunity

Whereas the role of KIR expression by CTLs is suggested mostly by genetic reports and studies performed on peripheral blood lymphocytes Martin et al. 2002 Momot et al. 2004 Namekawa et al. 2000 Snyder et al. 2003 Yen et al. 2001 , there is now strong, converging evidence indicating that NKG2D and CD94 NKG2 receptors play essential roles in the control of effector CTLs in tissues, controlling important disease processes. The presence of abundant melanoma-specific CTLs in patients with...

Role of MICNKG2D in Autoimmune Diseases

Because ligand binding unconditionally triggers NKG2D without counterbalance by a known antagonist, its dysregulation together with anomalous expression of MIC in local tissue sites may promote autoreactive T cell stimulation. Indeed, recent evidence indicates that MIC-NKG2D may play important roles in the pathogenesis of several autoimmune diseases. In rheumatoid arthritis RA , the severity of autoimmune and inflammatory joint disease correlates with large numbers of CD4 CD28- T cells, which...