Systemic Lupus Erythematosus The Prototypic Immune Complex Mediated Disease

SLE is a chronic, remitting and relapsing, multisystem autoimmune disease that affects predominantly women, with an incidence of 1 in 700 among women between the ages of 20 and 60 years (about 1 in 250 among black women) and a female-to-male ratio of 10 : 1. The principal clinical manifestations are rashes, arthritis, and glomerulonephritis, but hemolytic anemia, thrombocyto-penia, and CNS involvement are also common. Many different autoantibodies are found in patients with SLE. The most frequent are antinuclear, particularly anti-DNA, antibodies; others include antibodies against ribo-nucleoproteins, histones, and nucleolar antigens. Immune complexes formed from these autoantibodies and their specific antigens are responsible for glomerulonephritis, arthritis, and vasculitis involving small arteries throughout the body. Hemolytic anemia and thrombocytopenia are due to autoantibodies against erythrocytes and platelets, respectively. The principal diagnostic test for the disease is the presence of antinuclear antibodies; antibodies against double-stranded native DNA are specific for SLE.

Osteoarthritis

Osteoarthritis

Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

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