Inhibits leukocyte recruitment into sites of inflammation

Rheumatoid arthritis, psoriasis

p40 chain of IL-12 and IL-23

Inhibits Th1 and TH17 responses

Inflammatory bowel disease, psoriasis

IL-2 receptor (CD25)

Inhibits IL-2-mediated T cell proliferation

Acute graft rejection


May be multiple effects on TH1 differentiation, antibody production

Systemic lupus erythematosus

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