Lymphoproliferation; T cell infiltrates in multiple organs, especially heart; lethal by 3-4 weeks

Failure of anergy in CD4+ T cells; defective function of regulatory T cells

CTLA-4 polymorphisms associated with several autoimmune diseases


Anti-DNA and other autoantibodies; immune complex nephritis; arthritis; lymphoproliferation

Defective deletion of anergic self-reactive B cells; reduced deletion of mature CD4+ T cells

Autoimmune lymphoproliferative syndrome (ALPS)


Multiorgan lymphocytic infiltrates, wasting

Deficiency of functional regulatory T cells

Was this article helpful?

0 0


Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

Get My Free Ebook

Post a comment