Diseases Caused by Cytokine Mediated Inflammation

Th1 Mediated Damage

In immune-mediated inflammation, TH1 and TH17 cells secrete cytokines that recruit and activate leukocytes. IL-17, produced by TH17 cells, promotes neutrophil recruitment interferon-y IFN-y , produced by TH1 cells, activates macrophages and tumor necrosis factor TNF and chemokines, produced by T lymphocytes and other cells, are involved in the recruitment and activation of many types of leukocytes. Tissue injury results from the products of activated neutrophils and macrophages, such as...