Figure 775

Rapid reaction of the adrenal cortex of a rat to stress caused by fracture of the tibia and fibula at time zero. (In the rat, corticos-terone is secreted in place of cortisol.) (Courtesy Drs. Guillemin, Dear, and Lipscomb.) dramatically by the experiment shown in Figure 77-5, in which corticosteroid formation and secretion increased sixfold in a rat within 4 to 20 minutes after fracture of two leg bones. Some of the different types of stress that increase cortisol release are the following 4....

Cortisol Prevents the Development of Inflammation by Stabilizing Lysosomes and by Other Effects Cortisol has the

Cortisol stabilizes the lysosomal membranes. This is one of its most important anti-inflammatory effects, because it is much more difficult than normal for the membranes of the intracellular lysosomes to rupture. Therefore, most of the proteolytic enzymes that are released by damaged cells to cause inflammation, which are mainly stored in the lysosomes, are released in greatly decreased quantity. 2. Cortisol decreases the permeability of the capillaries, probably as a secondary effect of the...