M Pneumoniae

M. pneumoniae is an important causative agent of upper and lower respiratory tract diseases. The most frequent extrapulmonary manifestations include encephalopathy, Guillain-Barre syndrome, perimyocarditis, and arthritis. Overall, these manifestations occur in less than 10 of patients, mostly in association with respiratory tract disease. There is no evidence of a predisposition of immunocompromised patients for severe or extrapulmonary M. pneumoniae infection. When diagnosis of M. pneumoniae...

Types Of Enzymes

Dihydropyrimidine dehydrogenase (DPD EC 1.3.1.2), the first and rate-limiting enzyme in the three-step catabolic pathway of the endogenous pyrimidine bases uracil and thymine, also catalyzes the reduction of 5-fluorouracil (5-FU) to dihydrofluorouracil. The human DPD enzyme is a homodimer of a 111-kDa subunit with 1025 amino acids residues containing FMN, NADPH, and flavin adenine nucleotide (FAD) binding sites the enzyme is encoded by a single gene (DPYD gene) with 23 exons mapped to...

Lyme Disease

The causative agent of Lyme disease, B. burgdorferi, was first identified in 1982, 6 five years after the description of an epidemic of arthritis cases among children in Lyme, Connecticut. Lyme disease occurs following the transmission of B. burgdorferi to a patient via the bite of an infected tick. Infection is often accompanied by a distinctive bulls eye rash, erythema migrans EM , which occurs in 60-80 of cases, or it may occasionally be associated with acrodermatitis chronicum atrophicans...