Paraneoplastic Syndromes

Several paraneoplastic manifestations are associated with the hematological malignancies, particularly the lymphomas. In several instances, autoimmune disorders such as Sjogren's disease, rheumatoid arthritis, SLE, and autoimmune thyroiditis precede the development of the lymphoma by several years. While tests supporting a diagnosis of autoimmune phenomena such as platelet antibodies, direct antiglobulin tests, antineutrophil and antiphospholipid antibodies are positive in approximately 40% patients with NHL, clinically relevant problems are seen in a minority of patients (<10%).91

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