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Despite intense research efforts and major advances in the understanding of particular aspects of the disease process, the etiology of SSc is still unknown and the pathogenesis only partly understood. Thus the concept that SSc evolves along pathological changes of the vascular system, the immune system and of the extracellular matrix has not significantly changed over the last twenty years. Nevertheless, survival has markedly improved over the past two decades, with a 5-year survival rate over 80%, although to date there is no proven effective disease-modifying treatment of SSc. This is due to significant breakthroughs in the treatment of several individual end-organ manifestations. Current therapies of SSc rely mainly on drugs directed to the major skin and visceral complications such as Raynaud's phenomenon, digital ulceration, nephropathy, gastrointestinal and pulmonary involvement. Although the introduction of drugs that treat these complications has changed markedly, the mortality and life quality of subgroups of SSc, the associated side effects and lack of efficacy in certain subgroups of organ involvement indicate that the available treatment options are often still unsatisfactory (e.g. digital ulceration, pulmonary fibrosis, kidney failure). Therefore, future treatments should specifically modulate distinct pathogenetic events in SSc.


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Treating Rheumatoid Arthritis With Herbs Spices Roots

Treating Rheumatoid Arthritis With Herbs Spices Roots

Did You Know That Herbs and Spices Have Been Used to Treat Rheumatoid Arthritis Successfully for Thousands of Years Do you suffer with rheumatoid arthritis Would you like to know which herbs and spices naturally reduce inflammation and pain 'Treating Rheumatoid Arthritis with Herbs, Spices and Roots' is a short report which shows you where to start.

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