MS, approval pending for Crohn's disease and RA
Abbreviations: APC, antigen presenting cell; IL, interleukin; JRA, juvenile rheumatoid arthritis; MS, multiple sclerosis; RA, rheumatoid arthritis; TNF, tumor necrosis factor.
infections have been associated with this group of biologic agents with infliximab having (P < .0001) more frequent serious infections when compared with Etanercept . Infliximab has a more lasting neutralizing effect . Etanercept offers a partial blockade allowing protective mechanisms of TNF-a to be present during infection . Although controversy exists in increased rates of overall infection when compared with disease-modifying antirheumatic drugs , there is little question regarding increased rates of extrapulmonary tuberculosis (TB) and serious infections of intracellular bacteria or endemic mycoses.
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