Prevalence

The disease is considered to be a relatively rare disorder; however, as yet there are no adequate epidemiological studies regarding its overall prevalence. The prevalence of MC presents great geographic heterogeneity, being more common in

Table 1

Demographic, clinical and serological features of 210 MC patients

Table 1

Demographic, clinical and serological features of 210 MC patients

Female/Male ratio

3.7:1

Mean age disease onset (yrs)

5311.6

Mean age at diagnosis (yrs)

56.4+11.2

Mean disease duration (yrs)

10.5 + 7.3

Purpura

98%

Weakness

100%

Arthralgias

98%

Arthritis

7%

Raynaud's phenomenon

48%

Sicca syndrome

53%

Skin ulcers

22%

Peripheral neuropathy

80%

Liver involvement

77%

Renal involvement

30%

Lung involvement

2%

Diffuse vasculitis

6.2%

Hyperviscosity syndrome

0.5%

B-cell lymphoma

10%

Hepatocellular carcinoma

3.3%

Thyroid cancer

1%

MC type Il/type III ratio

2

Cryocrit %

4.4 + 11.7

Rheumatoid factor

98%

C4mg% (nv 20-60)

11+7.7

C3mg% (nv 90-180)

100 + 28

Autoantibodiesa

56%

Anti-HCV Ab + HCV RNA

92%

Anti-HBV Ab

42%

HBsAg

9%

a Autoantibodies: anti-nuclear and/or anti-mithocondrial, and/or anti-smooth muscle antibodies.

a Autoantibodies: anti-nuclear and/or anti-mithocondrial, and/or anti-smooth muscle antibodies.

Southern Europe than in Northern Europe or Northern America (Gorevic et al., 1980; Ferri et al., 2002a, 2004).

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