Inhibitors of Nucleic Acid Metabolism

Whereas the drugs described so far functionally or physically influence immune cells involved in the pathogenesis of LE, mycophenolate mofetil (MMF) and leflunomide were shown to decrease T- and B-cell proliferation by interfering with purine and pyrimidine metabolism, respectively. Whereas MMF is well established within transplantation medicine, leflunomide is licensed for use in rheumatoid arthritis. Both drugs have been used outside these indications in the context of LE (Furst 1999, Jayne 1999, Kurtz et al. 1995). MMF was shown to be effective for DLE and SCLE at doses of

2g/d (Boehm and Bieber 2001, Goyal and Noussari 2001,Hanjani and Noussari 2002, Karim and Alba 2002, Schanz et al. 2002), whereas leflunomide was shown to positively influence accompanying cutaneous symptoms when applied for arthritic symptoms within SCLE as the main therapeutic target (10-20 mg/d) (Glant et al. 1998, Parnham 1995, Remer and Weisman 2001). However, gastrointestinal side effects, mainly diarrhea for MMF and hematologic and hepatic disturbances for leflunomide, may be limiting clinical application.

Was this article helpful?

0 0


Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

Get My Free Ebook

Post a comment