Clinical background

SCLE patients have four or more American College of Rheumatology (ACR) criteria for the classification of SLE in approximately 50% of cases (Sontheimer et al., 1979). Those SLE patients with SCLE generally have a mild systemic disease, with a low incidence of glomerulonephritis, arthritis, serositis, and with a mild neurological involvement (Callen and Klein, 1988).

Anti-SSA antibodies are very frequently observed (up to 90% of the cases) and their prevalence increases if repeated evaluations are made during follow-up.

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