MTcFdg Petct in Rheumatoid Arthritis

The fact that 18F-FDG in inflamed joints was first reported by Yasuda et al. (1996) and, most recently, 18F-FDG PET-CT has been used for the diagnosis of early rheumatoid arthritis (Beckers et al. 2004). 18F-FDG PET-CT was systematically applied to the monitoring of disease activity by simultaneous multiarticular assessment. The knees and either the wrists and finger joints or the ankles and first metatarso-phalangeal joints were evaluated individually and globally (Fig. 10.9). Parameters derived from PET-CT and clinical, biological, and so-nographic parameters were correlated. This study has confirmed that metabolic activity is significantly increased in synovitis in active rheumatoid arthritic joints. The diagnostic use of 18F-FDG PET-CT is expected for more effective treatment of early rheumatoid synovitis. Figure 10.51 shows an incidental finding of 18F-FDG uptake in a patient with rheumatoid arthritis who developed diffuse large B-cell

Pet Scan Rheumatoid Arthritis

lymphoma of the colon as a complication of prolonged administration of methotrexate and hydrocortisone for the treatment of rheumatoid arthritis.

99mtc Mdp Bone Scan

Fig. 10.51A, B 99mTc-MDP bone scan and 18F-FDG PET in rheumatoid synovitis. A 99mTc-MDP bone scan shows mottled uptake in the shoulder joints denoting arthritis (arrows). B 18F-FDG PET reveals exactly the same finding (arrows). Arthritis was incidentally diagnosed on PET performed for metastases that are indicated by scattered hot areas

Fig. 10.51A, B 99mTc-MDP bone scan and 18F-FDG PET in rheumatoid synovitis. A 99mTc-MDP bone scan shows mottled uptake in the shoulder joints denoting arthritis (arrows). B 18F-FDG PET reveals exactly the same finding (arrows). Arthritis was incidentally diagnosed on PET performed for metastases that are indicated by scattered hot areas

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