Proinflammatory mediator; pleiotropic; proinflammatory gene inducer; induces fever, chills, acute phase proteins, anorexia, hypotension, and neutrophilia

Normal phenotype

Clinical treatment for bone marrow reconstitution; adjuvant for tumor vaccines; anti-IL-la used to treat rheumatoid arthritis; side effects include flulike symptoms, hypotension, acute phase response, and capillary leak syndrome;

proinflammatory agent or hematopoiesis stimulator

Alternative Protein Genetic Cellular Up regulators of . , Target cells ^ . , . Clinical

, , , . • 1 . • • • regulators of ,, Functional properties expression ... , . , , , nomenclature characteristics characteristics expression expression . and/or tissues , . c utility/animal models expression analysis


Protein: 17.5



LPS, bacteria,

IL-2, IL-3, IL-4,


Proinflammatory mediator;

Normal phenotype,

Vaccine adjuvant;


kDa (h), 31 kDa;

location: 2ql3-

macrophages, B

virus, cAMP, IL-1,

IL-6, IL-10, IL-


proinflammatory gene

less acute phase

enhancement of bone



q21 (h); 2 (m);

cells, T

IL-2, IL-3, IFN-a,

13, IFN-y, TGF-

fibroblasts, T

inducer; induces fever, chills,

response and fever

marrow reconstitution;


(inactive): 269

exons: six;

lymphocytes, B

IFN-p, IFN-y, TNF-



acute-phase proteins,

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Treating Rheumatoid Arthritis With Herbs Spices Roots

Treating Rheumatoid Arthritis With Herbs Spices Roots

Did You Know That Herbs and Spices Have Been Used to Treat Rheumatoid Arthritis Successfully for Thousands of Years Do you suffer with rheumatoid arthritis Would you like to know which herbs and spices naturally reduce inflammation and pain 'Treating Rheumatoid Arthritis with Herbs, Spices and Roots' is a short report which shows you where to start.

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