Animal Models for SLE
bodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: Findings in open-label and randomized placebo-controlled trials. Arthritis Rheum. 43:2383-2390.
Cohen, P.L. and Eisenberg, A. 1991. Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243-269.
Cohen, P.L. and Eisenberg, R.A. 1992. The lpr and gld genes in systemic autoimmunity: Life and death in the Fas lane. Immunol. Today 13:427428.
Cornall, R.J., Cyster, J.G., Hibbs, M.L., Dunn, A.R., Otipoby, K.L., Clark, E.A., and Goodnow, C.C. 1998. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8:497-508.
Datta, S.K. 1989. A search for the underlying mechanisms of systemic autoimmune disease in the NZB x SWR model. Clin. Immunol. Immu-nopathol. 51:141-156.
Dorner, T. and Putterman, C. 2001. B cells, BAFF/zTNF4, TACI, and systemic lupus erythematosus. Arthritis Res. 3:197-199.
Fadok, V.A., Bratton, D.L., and Henson, P.M. 2001. Phagocyte receptors for apoptotic cells: Recognition, uptake, and consequences. J. Clin. Invest. 108:957-962.
Griffith, T.S., Brunner, T., Fletcher, S.M., Green, D.R., and Ferguson, T.A. 1995. Fas ligand-in-duced apoptosis as a mechanism of immune privilege. Science 270:1189-1192.
Howie, J.B. and Helyer, B.J. 1968. The immunology and pathology of NZB mice. Adv. Immunol. 9:215-266.
Lahita, R.G. 2000. Sex hormones and systemic lupus erythematosus. Rheum. Dis. Clin. North. Am. 26:951-68.
Lynch, D.H., Watson, M.L., Alderson, M.R., Baum, P.R., Miller, R.E., Tough, T., Gibson, M., DavisSmith, T., Smith, C.A., Hunter, K. et al. 1994. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1:131-136.
Majeti, R., Xu, Z., Parslow, T.G., Olson, J.L., Daikh, D.I., Killeen, N., and Weiss, A. 2000. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell 103:1059-1070.
Maldonado, M.A., Eisenberg, R.A., Roper, E., Cohen, P.L., and Kotzin, B.L. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J. Exp. Med. 181:641-8.
Newton, C.R., Graham, A., Heptinstall, L.E., Powell, S.J., Summers, C., Kalsheker, N., Smith, J.C., and Markham, A.F. 1989. Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acids Res. 17:2503-2516.
O'Connell, J., O'Sullivan, G.C., Collins, J.K., and Shanahan, F. 1996. The Fas counterattack: Fasmediated T cell killing by colon cancer cells expressing Fas ligand. J. Exp. Med. 184:10751082.
Roark, J.H., Kuntz, C.L., Nguyen, K.A., Mandik, L., Cattermole, M., and Erikson, J. 1995. B cell selection and allelic exclusion of an anti-DNA Ig transgene in MRL-lpr/lpr mice. J. Immunol. 154:4444-4455.
Roths, J.B., Murphy, E.D., and Eicher, E.M. 1984. A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. J. Exp. Med. 159:1-20.
Sato, S., Ono, N., Steeber, D.A., Pisetsky, D.S., and Tedder, T.F. 1996. CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. J. Immunol. 157:4371-4378.
Seo, S.J., Fields, M.L., Buckler, J.L., Reed, A.J., Mandik-Nayak, L., Nish, S.A., Noelle, R.J., Turka, L.A., Finkelman, F.D., Caton, A.J., and Erikson, J. 2002. The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity 16:535-546.
Suda, T., Takahashi, T., Golstein, T., and Nagata, S.
1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169-1178.
Takahashi, T., Tanaka, M., Brannan, C.I., Jenkins, C.I., Copeland, N.G., Suda, T., and Nagata, S.
1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969-976.
Watanabe-Fukunaga, R., Brannan, C.I., Itoh, N., Yonehara, S., Copeland, N.G., Jenkins, N.A., and Nagata, S. 1992. The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J. Immunol. 148:1274-1279.
Weintraub, J.P., Godfrey, V., Wolthusen, P.A., Cheek, R.L., Eisenberg, R.A., and Cohen, P.L. 1998. Immunological and pathological consequences of mutations in both Fas and Fas ligand. Cell. Immunol. 186:8-17.
Zhou, T., Bluethmann, H., Eldridge, J., Brockhaus, M., Berry, K., and Mountz, J.D. 1991. Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice. J. Immunol. 147:466-474.
Contributed by Philip L. Cohen and
Michael A. Maldonado University of Pennsylvania School of Medicine
Was this article helpful?