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Table 4.3.2 Models of Chronic GVHD

Host preparation

Experimental readouts

Genetic disparity

Common strain Organ-specific Autoimmune disease combinations pathology model (reference)

Lethally irradiated"

Sublethally irradiated

Unirradiated

Th2 clones

Th2 cytokines; serum IgE; lack of anti-host CTL; rheumatoid factor; antibodies to ssDNA, ribo-nucleoprotein, renal tubular antigens, and laminin

Minor histocompatibility antigens

Minor histocompatibility antigens

Skin

B10.D2 ^ BALB/c Skin

DBA/2 ^ B6D2F1 Kidneys

Scleroderma (DeClerck et al., 1986)

Scleroderma (Claman et al., 1985)

Glomerulonephritis (Kuppers et al., 1988) Systemic lupus (Kuppers et al., 1988) Salivary glands Sjogrens syndrome

(Fujiwara et al., 1991) Muscles Myositis

(Gelpi et al., 1994) Intestines Enteropathy

(de Geus et al., 1993) Rheumatoid arthritis (Pals et al., 1985) Scleroderma (Fujiwara et al., 1991)

Primary biliary cirrhosis (Saitoh et al., 1991) Kidneys Lupus nephritis

Joints

Nails

Liver aLow doses (2 x 107) of splenic T cells produce a CGVHD in the LP ^ B6 strain combination; larger T cell inocula (5 x 107) result in lethal AGVHD. ^Sublethal irradiation (600 rad) is necessary to generate chronic GVHD in the B10.D2 ^ BALB/c strain combination. Higher doses of irradiation produce lethal AGVHD.

Animal Models of Acute and Chronic Graft-Versus-Host Disease

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