Effect of expression analysis^

Clinical utility/animal models

Reduced host defense against infection; loss of germinal centers

Clinical use of anti-TNF reduces rheumatoid arthritis, Crohn's disease, congestive heart disease; elevated levels in sepsis, fever, infections, cancer, GVHD, SLE, asthma, multiple sclerosis

Alternative Protein Genetic Cellular Up regulators of , ^ ~ Target cells ^ . , . Clinical

Cytokine , A , A . . , A . . . . regulators ot 1( . Functional properties expression 1 1 1

nomenclature characteristics characteristics expression expression . and/or tissues , . c utility/animal models expression analysis

Thymic stromal

Protein: 18-23


Thymus, spleen,

B cells

Stimulates B-cell


kDa (h), 16.2-24

location: 5q22.2

kidney, lung, bone

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