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Table 15.4.1 Incidence ofAdjuvant-lnduced Arthritis in Various Rat Strains

Rat strains RT1 haplotype Incidence"

Outbred

Inbred

Buffalo (Buf) b 50%b

Brown Norway (BN) n 100%b

MAXX n 100%

Dark Agouti (DA) av1 100%

Wistar King Aptekman k 75% (WKA)

Fisher (F344) lv1 20%

aIncidence in rats weighing 150 to 300 g.

Strains Buffalo and Brown Norway exhibit sex differences in AA susceptibility. In Buffalo, males are resistant and incidence is reported for females; in Brown Norway, females are resistant and incidence is reported for males.

Adjuvant Arthritis in the Rat

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