Info

Up regulators of expression

Down regulators of expression

Target cells and/or tissues

Functional properties

Effect of expression analysis^

Clinical utility/animal models

Neurotrophic factor; important in development/maintenance of nervous system; promotes survival and outgrowth of neurons

Neurotrophic factor; supports survival and outgrowth of sensory neurons

Alternative Protein Genetic Cellular Up regulators of , ^ ~ Target cells ^ . , . Clinical

Cytokine , A , A . . , A . . . . regulators ot 1( . Functional properties expression 1 1 1

nomenclature characteristics characteristics expression expression . and/or tissues , . c utility/animal models expression analysis

Protein: 28-32 kDa (h); precursor: 252 aa (h), 263 aa (m); mature: 196 aa (h), 239 aa (m); quaternary structure: monomer; secondary structure: four a-helical bundles; similar proteins: structurally similar to LIF, CNTF, IL-6, G-CSF, IL-11; glycosylation: 2 (h) and 3 (m) potential N-linked glycosylation sites; disulfide bonds: two (h), zero (m)

Chromosomal location: 22ql2.2 (h), 11 (m); exons: three; introns: two

T cells, monocytes, macrophages, bone marrow, testis, Kaposi's sarcoma, spleen, embryonic gonads, testis

PMA, IL-2, IL-3, erythropoietin, PHA, anti-CD28

Hematopoietic progenitors, fibroblasts, chondrocytes, astrocytes, smooth muscle cells, Kaposi's sarcoma, neurons, tumor cells

Regulates hematopoietic cell growth and differentiation; modulates cell growth and differentiation in neurogenesis and osteogenesis; inhibits tumor growth; stimulates fiboblasts, smooth muscle cell, and Kaposi's sarcoma proliferation; induces cytokine expression by endothelial cells; induces LDL-R expression

Elevated levels seen in SLE and rheumatoid arthritis; in animal models, increases platelets without causing anemias

Cytokine

Osteopontin

Alternative

Protein

Genetic

Cellular

Up regulators of

nomenclature

characteristics

characteristics

expression

expression

Bone

Protein: 45-75

Chromosomal

Bone,

BMP-7, EGF,

phosphoprotein

kDa; precursor:

location: 4q21-

preosteoblasts,

PDGF, retinoic

(BPP), 2ar, 2B7,

314 aa (h), 294

q25 (h), 5 (m);

osteoblasts,

acid, TGF-(3,

44-kDa bone

aa (m); mature:

exons: six to

osteoclastic cells,

vitamin D3,

phosphoprotein

298 aa (h);

seven; introns: five

kidney, metrial

mechanical stress,

(44K BPP), 66-

quaternary

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