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NKR-P1A, killer cell lectin-like receptor subfamily B, member 1

100-120 kDa type I transmembrane protein, zone dependent metalloprotease domain, disintegrin domains

42-45 kDa ADP ribosyl cyclase single-chain GPI-anchored protein

A family of 14 members with two (KIR2) or three (KIR3) Ig-like domains and differing cytoplasmic domains, some with and some lacking inhibitory (ITIM) motifs

43 kDa glycoprotein, C-type lectin family, two cytoplasmic ITIM motifs, expressed as heterodimer with CD94

27 kDa Ig superfamily (KIR family), on surface as 80 kDa disulfide-linked multimer 40 kDa type II glycoprotein, expressed as disulfide-bonded homodimer

Monocytes, macrophages, PMN, T cells, endothelial cells, myocytes

Monocytes, granulocytes, lymphoid progenitors (appears prior to IgH or TCR rearrangement), bone marrow stromal lines, HUVEC, FDC NK cells and a subset of CD8+ T cells

NK cells

NK cells, cytotoxic T cells, intestinal intraepithelial lymphocytes

Most NK cells, subset of

CD4 and CD8 T cells

Sheddase which converts plasma membrane TNF-a, TNF-a receptor to soluble forms. Deletion of a catalytic domain is perinatally lethal. Not known

Research reagent

Interact with MHC Class I molecules on potential target cells, inhibiting or activating (depending on the intracellular sequence) cytotoxic function

Complex with CD94 binds HLA-E and is inhibitory to NK cell mediated cytoxicity

High soluble CD157 in serum of severe rheumatoid arthritis

Research reagent

Research reagent

Role in costimulation of NK Research reagent cells and CTL

Costimulation

Research reagent

Index

Other names

Molecular properties

Cellular expression

Function

Usefulness

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