A13

Skolnik, E.Y., Batzer, A., Li, N., Lee, C.H., Lowen-stein, E., Mohammadi, M., Margolis, B., and Schlessinger, J. 1993. The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260:1953-1955.

Suh, P.G., Ryu, S.H., Moon, K.H., Suh, H.W., and Rhee, S.G. 1988. Cloning and sequence of multiple forms of phospholipase C. Cell 54:161-169.

Takeda, K.,. Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T., and Akira, S. 1996. Essential role of Stat6 in IL-4 signalling. Nature 380:627-630.

Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251-255.

Taniuchi, I., Kitamura, D., Maekawa, Y., Fukuda, T., Kishi, H., and Watanabe, T. 1995. Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases. EMBO J. 14:3664-3678.

Tedder, T.F., Zhou, L.J., and Engel, P. 1994. The CD19/CD21 signal transduction complex of B lymphocytes. Immunol. Today 14:437-442.

Thierfelder, W.E., van Deursen, J.M., Yamamoto, K., Tripp, R.A., Sarawar, S.R., Carson, R.T., Sangster, M.Y., Vignali, D.A., Doherty, P.C., Grosveld, G.C., and Ihle, J.N. 1996. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382:171-174.

Thomis, D.C., Gurniak, C.B., Tivol, E., Sharpe, A.H., and Berg, L.J. 1995. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270:794-797.

Turner, M., Mee, P.J., Costello, P.S., Williams, O., Price, A.A., Duddy, L.P., Furlong, M.T., Geahlen, R.L., and Tybulewicz, V.L. 1995. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378:298302.

Veillette, A., Bookman, M.A., Horak, E.M., and Bolen, J.B. 1988. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55:301-308.

Voronova, A.F. and Sefton, B.M. 1986. Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion. Nature 319:682685.

Wang, L.M., Keegan, A., Frankel, M., Paul, W.E., and Pierce, J.H. 1995. Signal transduction through the IL-4 and insulin receptor families. Stem Cells (Dayt) 13:360-368.

Wange, R.L. and Samelson, L.E. 1996. Complex complexes: Signaling at the TCR. Immunity 5:197-205.

Weiss, A., Koretzky, G., and Schatzman, R. 1991. Functional activation of the T cell antigen receptor induces tyrosine phosphorylation of phospholipase Cg1. Proc. Natl. Acad. Sci. U.S.A. 88:5484-5488.

White, M.F. 1996. The IRS-signalling system in insulin and cytokine action. Phil. Trans. R. Soc. Lond. B Biol. Sci. 351:181-189.

Wilks, A.F., Harpur, A.G., Kurban, R.R., Ralph, S.J., Zurcher, G., and Ziemiecki, A.. 1991. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell Biol. 11:2057-2065.

Witthuhn, B.A., Silvennoinen, O., Miura, O., Lai, K.S., Cwik, C., Liu, E.T., and Ihle, J.N. 1994. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153-157.

Woodrow, M., Clipstone, N.A., and Cantrell, D. 1993. p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178:1517-1522.

Zhang, R., Alt, F.W., Davidson, L., Orkin, S.H., and Swat, W. 1995. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470-473.

Contributed by John J. O'Shea National Institute of Arthritis and

Musculoskeletal and Skin Diseases Bethesda, Maryland

James A. Johnston DNAX

Palo Alto, California John Kehrl

National Institute of Allergy and

Infectious Diseases Bethesda, Maryland

Gary Koretzky

University of Iowa College of Medicine Iowa City, Iowa

Lawrence E. Samelson

National Institute of Child Health and

Human Development Bethesda, Maryland

Key Molecules Involved in Receptor-Mediated Lymphocyte Activation

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